“Strategies aimed at minimizing adaptive immunity to AAV vectors or reducing the need for repeat administration continue within the field. Removing CpG motifs from AAV vectors or designing hybrid AAV capsids has been shown to reduce innate and adaptive immune responses following intramuscular delivery [Faust et al.].”
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June 4th, 2018 - Sebastian et al. 2015, In vivo Gene Correction of Cystic Fibrosis; Cystic Fibrosis in the Light of New Research (Book): Chapter 15, DOI: 5772/60697.
