May 25th, 2021—NxGEN Vector Solutions announces today that the U.S. Patent and Trademark Office has issued a new Patent, No. 11,015,210, further strengthening the Company’s intellectual property position and coverage for the Company’s CpG-depletion AAV Vector Technology.
The ‘210 patent, entitled, “Constructs and Methods for Delivering Molecules via Viral Vectors with Blunted Innate Immune Responses,” covers a modified recombinant adeno-associated viral vector to reduce the number of CpG di-nucleotides such that an immune response to the vector is reduced.
There are four independent claims and they are drawn to various AAV vector compositions in which the regulatory sequence and the exogenous sequence of the AAV vector is CpG-reduced or CpG-free and the AAV ITRs are wild type or CpG-reduced. The regulatory sequence can be a promoter, an enhancer, an intron, a microRNA, or a polyA signal sequence.
The issued patent demonstrates NxGEN Vector Solutions’ commitment to developing innovative therapies that improve AAV gene therapy outcome by establishing persistent transgene expression, evading immunity, and minimizing infiltration of effector cells. We are pleased with the issuance of the patent and excited about the potential of this technology–which is already being used in clinical trials and has quickly become an industry standard–to improve the safety and efficacy of gene therapies and to ensure that patients who receive gene therapy maintain their therapeutic gene expression.
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